A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A
We previously found that treatment with highly purified TFIIH corrected the NER defect of cells from individuals with TTD-A, but none of the nine genes encoding TFIIH were mutated in these individuals ...
The repair-deficient form of trichothiodystrophy (TTD) most often results from mutations in the genes XPB or XPD, encoding helicases of the transcription/repair factor TFIIH. The genetic defect in a ...
Scientists at The Scripps Research Institute have determined the crystal structure of an enzyme called xeroderma pigmentosum group B (XPB) helicase, identifying several unexpected functions and ...
Two of DNA's worst enemies, ultraviolet light and chemical carcinogens, can wreak havoc on the molecule by mutating individual nucleotides or changing its physical structure. In most cases, genomic ...
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