A new study of 450 colorectal cancer patients has delivered some of the clearest evidence yet that mutations in two DNA proofreading genes, POLE and POLD1, can identify which patients are most likely ...

Why do some people develop cancer while others, exposed to seemingly similar environments and living comparable lifestyles, ...

C EGFR T790M gene variant face roughly 25 times the lung cancer risk of noncarriers, according to the largest-yet study of ...

Consider a living cell, which can have thousands of genes. Now think of these genes as dials that can be tweaked to change how the cell grows in a given environment. Tweaking a gene can either ...

In simple terms: a mutation is a stable change in genetic sequence that can be copied when cells or viruses replicate. Most mutations have no detectable effect, some contribute to disease, and a small ...

Lung cancer is so closely associated with smoking that people who have never smoked may assume their risk is extremely low.

CFTR is a protein essential to wet surfaces throughout your body, like the airways of your lungs. People with cystic fibrosis have a gene mutation that causes problems with the protein. Some ...