Endothelin biology remains an attractive therapeutic target in IgA nephropathy where intrarenal endothelin-1 expression is upregulated and implicated in nephron loss through vasoconstriction, ...

Immunoglobulin A (IgA) nephropathy is an autoimmune disease characterized by the deposition of circulating IgA-containing immune complexes (IgA-ICs) in the glomerular mesangium, leading to mesangial ...

IgA nephropathy (IgAN) is a kidney disorder caused by a buildup of immune complexes and the antibody called immunoglobulin A (IgA) inside the kidneys. This buildup causes inflammation in the kidneys.

STOCKHOLM, March 4, 2021 /PRNewswire/ -- Calliditas Therapeutics AB (publ) ("Calliditas") today announced that it will host a Key Opinion Leader (KOL) Perspectives webinar on the Pathophysiology and ...

Panelists discuss how novel targeted therapies for immunoglobulin A (IgA) nephropathy are transforming treatment paradigms by specifically addressing the underlying pathophysiology of the 4-hit ...

IgA nephropathy, also known as Berger’s disease, is a progressive, autoimmune, chronic kidney disease that predominantly affects adults between the ages of 20 and 40. It is characterized by the ...

Panelists discuss how immunoglobulin A (IgA) nephropathy develops through a complex 4-hit cascade involving aberrant IgA1 glycosylation, anti-glycan antibody formation, immune complex deposition, and ...

IgA nephropathy mainly affects the kidneys, while IgA vasculitis can also involve your skin, joints, and digestive system. IgA vasculitis often appears suddenly with rash and pain, but IgA nephropathy ...

By Siddhi Mahatole and Sriparna Roy June 4 (Reuters) - Otsuka Pharmaceutical said on Thursday its drug in a late-stage study preserved kidney function over 12 months in patients with a type of ...

IgA nephropathy (IgAN), also known as Berger disease, occurs when high levels of immunoglobulin A (IgA) antibodies accumulate in the kidneys. This causes inflammation and scarring in the glomeruli, ...