An outstanding question is how reward context contributes to cerebellar function. Classical models posit that granule cells signal sensorimotor context. The incorporation of reward, reward-omission ...
Stress granules are droplet-like protein hubs that temporarily shield fragile RNA from cellular stresses such as toxins. VCP is a protein essential for breaking up stress granules and has been linked ...
The dentate gyrus (DG) is a region of the mammalian brain known to support the encoding of new memories. This brain region is part of the hippocampal formation, a set of brain regions involved in ...
We are interested in mechanisms that regulate RNA Stress Granule (SG) and Processing Body (P-body) formation in cells. These two types of RNA granules aggregate translationally-silenced mRNAs and ...
The dentate gyrus is the "input point" for the hippocampus part of the brain. It transmits information from the short term memory to the long term. It consists of granule cells, which are especially ...
Newborn granule cells show high excitability that disappears as the cells mature. Little has been known about the mechanisms that create low excitability in mature cells or how excitability of the ...
Stress granules are droplet-like protein hubs that temporarily shield fragile RNA from cellular stresses such as toxins. VCP is a protein essential for breaking up stress granules and has been linked ...
Cells respond to cellular stress by forming stress granules, molecular condensates containing non-translating messenger ribonucleoproteins. Stress granules form during chemotherapy and promote cell ...
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