We review Bayesian and Bayesian decision theoretic approaches to subgroup analysis and applications to subgroup-based adaptive clinical trial designs. Subgroup analysis refers to inference about ...

The ability to make adaptive decisions in uncertain environments is a fundamental characteristic of biological intelligence. Historically, computational ...

Ideally, specific treatment for a cancer patient is decided by a multidisciplinary tumor board, integrating prior clinical experience, published data, and patient-specific factors to develop a ...

The US FDA has issued draft guidance supporting the use of Bayesian statistical models in drug and biologic trials, enabling sponsors to integrate prior and real-world data into study designs. This ...

From within the dark confines of the skull, the brain builds its own version of reality. By weaving together expectations and information gleaned from the senses, the brain creates a story about the ...